Western Diets Turn on Fat Genes

Those extra helpings of gravy and dessert at the holiday table are even more of a problem to
your waistline than previously thought.

According to a new research report recently appearing online in
The FASEB Journal, a diet that is high in fat and in sugar actually switches on genes that ultimately cause our bodies to store too
much fat.

These foods strike you with a double-problem as the task of converting high-fat and high-sugar foods to energy is made even more difficult because these foods also turn our bodies into "fat-storage containers."

In the research report, scientists show that foods high in fat and
sugar stimulate a known opioid receptor, called the kappa opioid
receptor (KOR), which plays a role in fat metabolism. When this
receptor is stimulated, it causes our bodies to hang on to much
more fat than they'd do otherwise.

According to  the researchers involved in the study, "the data presented here support the hypothesis that overactivation of the kappa opioid receptors contribute to the development of obesity, especially during prolonged consumption of high-fat, calorically
dense diets."

To make this discovery, the research team conducted tests in two groups of laboratory subjects. One group had the kappa opioid receptor genetically deactivated and the other group was normal. Both groups were given a high fat, high sucrose, energy dense diet for 16 weeks. While the control group gained significant weight and fat mass on this diet, those with the deactivated receptor remained lean. In addition to having reduced fat stores, those with the deactivated receptor also showed a reduced ability to store incoming nutrients.

Although more work is required, this research may help address
the growing obesity problem worldwide in both the short-term and long-term. Most importantly, this research provides more proof that high-fat and high-sugar diets should be avoided. In the long-term, however, this research is even more significant, as it provides a specific target for developing therapies for preventing obesity and helping obese people slim down.

"In times when food was scarce and starvation an ever-present threat, an adaptation that allows our bodies to store as much energy as possible during plentiful times was probably a lifesaver. Conversely, by removing that opioid receptor, we may have found a way to keep us from eating ourselves to death." concluded the researchers.

FASEB (The Federation of American Societies for Experimental Biology) publishes online, Stanford University Library.

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